The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could result in a rise in methadone plasma concentrations, which could trigger most likely lethal respiratory melancholy. On top of that, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may cause an increase